ATRM: Arabidopsis Transcriptional Regulatory Map

Release Note
: the PlantTFDB 4.0 (See new features and the navigation in English and Chinese) is released. The TFs of Arabidopsis thaliana, Oryza sativa subsp. japonica, Oryza sativa subsp. indica are available at PlantTFDB.(2016-10-15)



   Transcriptional regulatory mechanisms of multiple processes in
A. thaliana
, one of the best-studied model plants, have been reported in a large amount of scientific literature, providing an opportunity to build up a high-quality
Arabidopsis
transcriptional regulatory network. Here, we used two data sources, PubMed Abstracts and ResNet Plant 3.0 (A commercial knowledgebase of Pathway Studio mined from both PubMed Abstract and full-texts of plant-specific journal, now called Pathway Studio Plant)to collect verified transcriptional regulatory interactions in
A. thaliana
. We retrieved transcription factor(TF)-associated interactions from ResNet Plant 3.0 as well as mined them from PubMed abstracts by MedScan. After manual curation each interaction by reviewing the original texts, we constructed an
Arabidopsis
transcriptional regulatory map (ATRM) that covers
388
TFs from
47
families, with directly supporting evidences from
974
references. This map mainly involves regulations in the developmental and stress response processes, providing a global landscape of transcriptional regulation in a plant species and also a valuable resource to study the architecture and evolution of plant transcriptional regulatory networks.
   For users to access this map conveniently, we constructed an interactive web portal powered by Cytoscape Web.

See ATRM by clicking this
    Through this website:
  1. ATRM can be visualized in kinds of styles and layouts.
  2. By double-clicking on nodes and edges, the information for corresponding genes and regulations are shown in the side panel, respectively. For genes, cross-links to PlantTFDB and TAIR for TFs and non-TFs are provided respectively. For regulations, cross-links to PubMed literature where regulations came are provided.
  3. Network data can be saved as different formats for further analysis.

How to Cite:
Jin JP, He K, Tang X, Li Z, Lv L, Zhao Y, Luo JC, Gao G. (2015). An Arabidopsis transcriptional regulatory map reveals distinct functional and evolutionary features of novel transcription factors. Molecular Biology and Evolution, 32(7):1767-1773. [Full Text (PDF), Supplementary Materials]